cyp2c19的重要性

发布网友 发布时间：2022-04-19 20:48

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热心网友 时间：2023-09-06 18:41

在2002年最多常用的200种处方药物中，大部分由P450酶负责代谢。而P450酶负责代谢的药物中，12%由CYP2C19代谢。由CYP2C19代谢的药物如下。
Drugs and other agents whose metabolic pathway cosegregates with the activity ofcytochrome P450 2C19invitroand/orin vivo Proton pump inhibitors
Omeprazole 5-hydroxylation;Lansoprazole 5-hydroxylation;
PantoprazoleO-demethylation;RabeprazoleN-demethylation
Anticonvulsants, hypnosedatives, muscle relaxants
Phenytoin 3’- and 4’-hydroxylation;(S)-Mephenytoin and nirvanol 4′-hydroxylation;Methylphenytoin 4′-hydroxylation;DiazepamN-demethylation (activation);Desmethyldiazepam hydroxylation;FlunitrazepamN-demethylation;
Phenobarbitalp-hydroxylation;(R)-Hexobarbital 3′-hydroxylation;
(R)-Mephobarbital 4-hydroxylation;CarisoprodolN-demethylation
Anti-infectives
Proguanil cyclisation (activation); Chlorproguanil cyclisation (activation);
Nelfinavir hydroxylation (activation)
Antidepressants
CitalopramN-demethylation; FluoxetineN-demethylation; SertralineN-demethylation; VenlafaxineO-demethylation (activation); ImipramineN-demethylation; ClomipramineN-demethylation; Trimipramine; AmitriptylineN-demethylation; Nortriptyline demethylation; MoclobemideC-hydroxylation
Others (mainlyin vitroevidence)
Thioridazine
Propranolol side-chain oxidation
Tolbutamide 4-hydroxylation
(R)-Warfarin 8-hydroxylation
Progesterone 21-hydroxylation
Testosterone oxidation at 17-position
Desogestrel 3α-hydroxylation (activation)
Cyclophosphamide 4-hydroxylation (active)
Ifosfamide 4-hydroxylation (active)
MethoxychlorO-demethylation (activation)